![]() If there is a recurrence of EE or GERD symptoms, an additional 4 to 8-week course of treatment should be considered.Weight 10 kg and greater: 10 mg orally once a day.Weight 3 to less than 5 kg: 2.5 mg orally once a day.Use: Treatment of heartburn and other symptoms associated with GERD Usual Pediatric Dose for Erosive Esophagitis Weight 20 kg and greater: 20 mg orally once a day.Weight 10 to less than 20 kg: 10 mg orally once a day.Weight 5 to less than 10 kg: 5 mg orally once a day.Use: Treatment of frequent heartburn (occurring 2 or more days a week) Usual Pediatric Dose for Gastroesophageal Reflux Disease Some patients may experience symptom relief within 24 hours of taking the first dose.This drug should be taken with a full glass of water prior to eating.A 14-day course of treatment may be repeated every 4 months.Over-the-Counter (OTC) formulations: 20 mg orally once a day in the morning Use: Treatment of heartburn and other symptoms associated with GERD Usual Adult Dose for Dyspepsia Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis) Usual Adult Dose for Gastroesophageal Reflux Disease Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis) Usual Adult Dose for Hypersecretory Conditions Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis) Usual Adult Dose for Zollinger-Ellison Syndrome Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis) Usual Adult Dose for Systemic Mastocytosis Some patients with Zollinger-Ellison Syndrome have been treated for longer than 5 years. The treatment duration should be for as long as clinically necessary. ![]() ![]() Doses higher than 80 mg should be given in divided doses.Maximum dose: 360 mg/day (as 120 mg orally 3 times a day) Usual Adult Dose for Multiple Endocrine Adenomas Maintenance of healing of EE due to acid-mediated GERD.Short-term treatment of EE due to acid-mediated GERD that has been diagnosed by endoscopy.If there is a recurrence of erosive esophagitis (EE) or gastroesophageal reflux disease (GERD) symptoms, an additional 4 to 8-week course of treatment should be considered.Patients who do not respond after 8 weeks of treatment may continue for an additional 4 weeks.Controlled studies for maintenance therapy did not extend past 12 months.Use: Short-term treatment of active benign gastric ulcer Usual Adult Dose for Erosive Esophagitis DUAL THERAPY: In combination with clarithromycin for the treatment of patients with H pylori infection and duodenal ulcer disease to eradicate H pylori.TRIPLE THERAPY: In combination with clarithromycin and amoxicillin for the treatment of patients with H pylori infection and active or a history of duodenal ulcer disease (within 1 year) to eradicate H pylori.Uses: Helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence Susceptibility testing should be performed in patients who fail treatment alternative antimicrobial therapy should be used when clarithromycin resistance is demonstrated, or susceptibility testing is not possible.Patients who failed therapy were more likely to develop clarithromycin resistance when they received dual therapy.Refer to the manufacturer product information for dosing for amoxicillin and/or clarithromycin.Antibiotic selection should be determined by local bacterial resistance, duration of treatment, and appropriate use.Patients presenting with an ulcer at the time of treatment should continue treatment with a 20 mg dose orally once a day for 14 days (dual therapy) or 18 days (triple therapy).Triple therapy: 20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin Use: Short-term treatment of active duodenal ulcer Usual Adult Dose for Helicobacter pylori InfectionÄual therapy: 40 mg orally once a day, taken concomitantly with clarithromycin Comment: If patients are not fully healed after 4 weeks, treatment may continue for another 4 weeks.
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